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Adjuvant Therapy of Breast Cancer : Cancer Treatment and Research - I. Craig Henderson

Adjuvant Therapy of Breast Cancer

Cancer Treatment and Research

By: I. Craig Henderson (Editor)

Hardcover

Published: 31st August 1992
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The results of randomized trials evaluating the use of early or adjuvant systemic treatment for patients with resectable breast cancer provide an eloquent rebuttal to those who would argue that we have made no progress in the treatment of cancer. Many of the tumors that we have been most successful in curing with chemotherapy and other newer forms of treatment are relatively uncommon. In contrast, breast cancer continues to be the single most common malignancy among women in the western world, is increasingly a cause of death throughout Asia and Third-World countries, and remains one of the most substantial causes of cancer mortality world­ wide. The use of mammography as a means of early detection has been shown to reduce breast cancer mortality by 25-35% among those popu­ lations in which it is utilized. The use of adjuvant systemic treatment in appropriate patients provides a similar (and additional) reduction in breast cancer mortality. Few subjects have been so systematically studied in the history of medicine, and it seems fair to conclude that the value to adjuvant systemic therapy in prolonging the lives of women with breast cancer is more firmly supported by empirical evidence than even the more conventional or primary treatments using various combinations ofsurgery and radiotherapy.

'Overall, this book is a useful review Volume containing thoughtful and up-to-date information on the optimal use of adjuvant therapy for breast cancer. It will be a valuable addition to the library of the practicing clinical oncologist.' Journal of the Nat. Cancer Inst. 85:10 1993

List of Contributors
Foreword to the Series
Introduction
Rationale and Methods for Studying Adjuvant Systemic Therapy
Evolving concepts in the adjuvant systemic therapy of operable breast cancerp. 3
Statistical methods for early breast cancer trialsp. 27
Results of Clinical Studies
The nature of the benefitp. 57
Adjuvant endocrine therapy of breast cancerp. 69
Adjuvant chemotherapy of axillary lymph-node-positive breast cancerp. 115
The node-negative problem: To treat or not to treatp. 147
Special Problems
Defining the high-risk breast cancer patientp. 161
Models for weighing benefits and toxicitiesp. 189
Financial considerations in the use of adjuvant chemotherapyp. 207
The use of adjuvant therapy in patients treated with conservative surgery and radiotherapyp. 223
Treating the relapsed patientp. 239
Future Directions
Unanswered questions in the adjuvant therapy of breast cancerp. 257
Neoadjuvant chemotherapyp. 279
Altering cell kinetics with endocrine therapyp. 293
Polypeptide growth factors: Their potential value in the management of breast cancer patientsp. 315
Immunotherapy of breast cancerp. 331
Breast cancer chemopreventionp. 357
App. I. Consensus statements from panels convened by The National Cancer Institute in 1980, 1985, 1990p. 371
App. II. List of completed and ongoing randomized clinical trials addressing questions related to the use of adjuvant systemic therapy to treat resectable breast cancerp. 395
Indexp. 455
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792316565
ISBN-10: 0792316568
Series: Cancer Treatment and Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 464
Published: 31st August 1992
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 2.6
Weight (kg): 2.5