Adjuvant Therapy of Breast Cancer

By: I. Craig Henderson

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Hardcover | 31 August 1992

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484 Pages

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25.4 x 17.78 x 2.69

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The results of randomized trials evaluating the use of early or adjuvant systemic treatment for patients with resectable breast cancer provide an eloquent rebuttal to those who would argue that we have made no progress in the treatment of cancer. Many of the tumors that we have been most successful in curing with chemotherapy and other newer forms of treatment are relatively uncommon. In contrast, breast cancer continues to be the single most common malignancy among women in the western world, is increasingly a cause of death throughout Asia and Third-World countries, and remains one of the most substantial causes of cancer mortality world wide. The use of mammography as a means of early detection has been shown to reduce breast cancer mortality by 25-35% among those popu lations in which it is utilized. The use of adjuvant systemic treatment in appropriate patients provides a similar (and additional) reduction in breast cancer mortality. Few subjects have been so systematically studied in the history of medicine, and it seems fair to conclude that the value to adjuvant systemic therapy in prolonging the lives of women with breast cancer is more firmly supported by empirical evidence than even the more conventional or primary treatments using various combinations ofsurgery and radiotherapy.

Industry Reviews

'Overall, this book is a useful review Volume containing thoughtful and up-to-date information on the optimal use of adjuvant therapy for breast cancer. It will be a valuable addition to the library of the practicing clinical oncologist.' Journal of the Nat. Cancer Inst. 85:10 1993

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Non-Fiction Medicine Clinical & Internal Medicine Diseases & Disorders Oncology Chemotherapy Family & Health Popular Medicine & Health

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Published: 5th November 2012

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List of Contributors
Foreword to the Series
Introduction
Rationale and Methods for Studying Adjuvant Systemic Therapy
Evolving concepts in the adjuvant systemic therapy of operable breast cancer	p. 3
Statistical methods for early breast cancer trials	p. 27
Results of Clinical Studies
The nature of the benefit	p. 57
Adjuvant endocrine therapy of breast cancer	p. 69
Adjuvant chemotherapy of axillary lymph-node-positive breast cancer	p. 115
The node-negative problem: To treat or not to treat	p. 147
Special Problems
Defining the high-risk breast cancer patient	p. 161
Models for weighing benefits and toxicities	p. 189
Financial considerations in the use of adjuvant chemotherapy	p. 207
The use of adjuvant therapy in patients treated with conservative surgery and radiotherapy	p. 223
Treating the relapsed patient	p. 239
Future Directions
Unanswered questions in the adjuvant therapy of breast cancer	p. 257
Neoadjuvant chemotherapy	p. 279
Altering cell kinetics with endocrine therapy	p. 293
Polypeptide growth factors: Their potential value in the management of breast cancer patients	p. 315
Immunotherapy of breast cancer	p. 331
Breast cancer chemoprevention	p. 357
App. I. Consensus statements from panels convened by The National Cancer Institute in 1980, 1985, 1990	p. 371
App. II. List of completed and ongoing randomized clinical trials addressing questions related to the use of adjuvant systemic therapy to treat resectable breast cancer	p. 395
Index	p. 455
Table of Contents provided by Blackwell. All Rights Reserved.

Adjuvant Therapy of Breast Cancer

At a Glance

Hardcover

Industry Reviews

Shipping

How to return your order

Defective items

You Can Find This Book In

Other Editions and Formats

Paperback

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