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Activators and Inhibitors of Complement - Robert B. Sim

Activators and Inhibitors of Complement

By: Robert B. Sim (Editor)

Hardcover

Published: 1st October 1992
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The complement system is a group of proteins which plays a major role in the processing and removal of microorganisms and tissue breakdown products from the circulation and extracellular spaces. The system is activated by a wide range of targets, and activation leads to the production of opsonins, chemotaxis of granulocytes, cell lysis and other biological activities. Inappropriate overactivation of the system contributes to inflammatory tissue damage in the host, while inadequate activation leads to accumulation of immune complexes and other debris in the circulation, and susceptibility to infection. The biology and biochemistry of the system is now adequately understood, and attempts can be made to manipulate the activation and activities of the system for potential therapeutic purposes.
The reviews in this volume summarise what is known of the ways in which the complement system can be activated, by interaction with antibodies, microorganisms, cell debris, and complex carbohydrates and how the activities and activation of the system have been modified, accidentally or by design, in vitro or in vivo by drugs, venoms, particulate carbohydrates, specific antibodies, synthetic peptides and other reagents.

List of Contributors
The Complement Systemp. 1
The Structure of Immunoglobulins and Their Interaction with Complementp. 17
Non-Immunoglobulin Activators of the Complement Systemp. 37
Solid Phase Activators of the Alternative Pathway of Complement and Their Use in vivop. 69
Nucleophilic Compounds Acting on C3 and C4p. 107
Effects of Drugs, Venoms and Charged Polymers on the Complement System
Effects of Venoms of Different Animal Species on the Complement Systemp. 127
Drugs and Low Molecular Weight Compounds Affecting the Complement Systemp. 137
Action of Polyionic Substances on the Complement Systemp. 149
Monoclonal Antibodies Against the Terminal Complement Componentsp. 167
Autoantibodies Against Complement Components and Their Effects on Complement Activityp. 181
Use of Synthetic Peptides in Exploring and Modifying Complement Reactivitiesp. 201
Indexp. 233
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792318194
ISBN-10: 0792318196
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 239
Published: 1st October 1992
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 1.5
Weight (kg): 0.54