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ABC Transporters - 40 Years on - Anthony M. George

ABC Transporters - 40 Years on

By: Anthony M. George (Editor)

Paperback Published: 27th March 2019
ISBN: 9783319794891
Number Of Pages: 376

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  • Hardcover View Product Published: 23rd December 2015
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This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer's disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders

ISBN: 9783319794891
ISBN-10: 3319794892
Audience: General
Format: Paperback
Language: English
Number Of Pages: 376
Published: 27th March 2019
Publisher: SPRINGER VERLAG GMBH
Country of Publication: CH
Dimensions (cm): 23.39 x 15.6  x 2.06
Weight (kg): 0.55

Earn 513 Qantas Points
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