By: Wolfgang E. Berdel (Editor), H. Jurgens (Editor), T. Buchner (Editor), J. Ritter (Editor), J. Kienast (Editor)

Hardcover

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Transferring hematopoietic stem cells and immune cells has continued to be a promising therapeutic alternative and a fascinating area of cell biology as well as a field of persistent procedural problems. This explains why substantial parts of basic research on cell growth and differentiation, immune tolerance and antitumor effects, gene transfer, minimal residual disease and supportive care have settled around clinical transplantation in hematology and oncology. This second volume updates the current role of allogeneic and autologous transplantation in leukemias, lymphomas and solid cancers, including controversial strategies and novel experimental approaches. Outstanding representatives of leading groups guarantee first-hand information and indicate how we can work and cooperate more effectively to the benefit of our patients.

Cellular Therapy: Targets and Effectors
Adoptive Immunotherapy in Chimeras	p. 3
The Roles of the Chemokine SDF-1 and its Receptor CXCR4 in Human Stem Cell Migration and Repopulation of NOD/SCID and B2mnull NOD/SCID mice	p. 11
Towards Adoptive Immunotherapy Using High Affinity T Cell Receptors	p. 25
New Antigens and Avenues to Immunotherapy of Cancer	p. 29
Allogeneic Cell Therapy with Antigen-Specific Cytotoxic T Lymphocytes (CTL) for Malignant Melanoma	p. 37
New Conditioning Strategies in Allogeneic Stem Cell Transplantation
Intensification of the Conditioning Regimen for Patients with high-risk AML and MDS: 3 year Experience of using an 188Re - Labelled anti - CD 66 Monoclonal Antibody	p. 43
Dose Reduced Conditioning for Allogeneic Blood Stem Cell Transplantation from Sibling and Unrelated Donors in 51 Patients	p. 59
Pharmacokinetics of Conditioning Regimens	p. 74
Megadose Stem Cell Transplantation	p. 79
HD-Ara-C in the Conditioning Regimen for BMT in Acute Leukemias	p. 84
TBI-Based Reduced Intensity Conditioning with Allogeneic Hematopoietic Stem Cell Transplantation (SCT) in Patients with High-Risk Hematologic Malignancies	p. 91
Total Marrow Irradation (TMI), Busulfan, and Cyclophos-phamide for Allografting in Multiple Myeloma. A Pilot Study	p. 95
Stem Cell Mobilisation, Processing and Characteristics
A "Single" Delayed Application of G-CSF after Autologous Peripheral Blood Stem Cell Transplantation - A Pilot Study	p. 107
Factors Influencing PBPC Mobilisation and Collection in Haematological Malignancies	p. 111
Successful Purging of Stem Cell Products Using CD34 Selection	p. 116
Autologous Transplantation of Non-Cryopreserved HSCs in Oncologic Patients with Poor Prognosis: First Experience in the Ukraine	p. 130
A Randomized Comparison of Once Versus Twice Daily rhG-CSF (Filgrastim) for Stem Cell Mobilisation in Healthy Donors for Allogeneic Transplantation	p. 138
CD 133/CD34 Expression on Hematopoietic Stem-/Progenitor Cells and Acute Leukemic Blasts	p. 145
Identification of Minimal Residual Leukemia Applying Continuous Gating	p. 156
Cord Blood Transplantation
Pilot Study - Lymphocyte Subset Reconstitution after Cord Blood Transplantation	p. 167
Altered Growth Characteristics of Cord Blood afterin vivo Exposure of the Mother to Chemotherapy	p. 177
Mismatched Donor Transplantation
Bone Marrow Transplantation from Mismatched Unrelated Donors	p. 183
Immune Reconstitution after Haploidentical Stem Cell Transplantation	p. 190
Clinical Transplantation - Hematologic Malignancies
Autografting and Allografting for Chronic Lymphocytic Leukemia: Is there a Rationale?	p. 197
Results of Stem Cell Transplantation in Children with CML in Comparison with Treatment with Cytostatics alone or with Interferon alfa. Report of the Polish Children's Leukemia/Lymphoma Study Group	p. 205
Comparison of Allogeneic Matched Related Stem Cell Transplantation in 1st CR with Chemotherapy alone in Children with High-Risk AML	p. 210
Stem Cell Transplantation in Acute Myeloid Leukemia after Conditioning with Busulfan, Cyclophosphamide and Different Dosages of Etoposide (VP-16)	p. 219
The Occurrence of Acute Graft-Versus-Host Disease and Infectious Complications in Patients with Acute and Chronic Myeloid Leukemia who Underwent Allogeneic PeripheralBlood Stem Cell Transplantation	p. 228
Long-Term Survival after Stem Cell Transplant in Adult Acute Lymphoblastic Leukemia	p. 233
Clinical Transplantation - Solid Tumors Autologous Transplantation in Breast Cancer in Europe and EBMT Data	p. 245
First-Line and Salvage High-Dose Chemotherapy in Patients with Germ-Cell Tumors	p. 253
High Dose Chemotherapy in High-Risk Ewing Tumours: Results in 156 (EI)CESS Patients	p. 263
Rapid Sequence Tandem Transplant in Children with High-Risk Neuroblastoma	p. 270
Anti-Angiogenesis
Angiogenesis Inhibitor TNP-470 During Bone Marrow Transplant and in Minimal Residual Disease	p. 283
Challenges in the Treatment of Fungal Infections Prophylaxis of Fungal Infections in Neutropenic Patients with Hematologic Malignancies	p. 301
Subject Index	p. 309
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9783540421559
ISBN-10: 3540421556
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 323
Published: 11th November 2002
Dimensions (cm): 23.4 x 15.6  x 1.9
Weight (kg): 0.636