1300 187 187
This volume presents an overview of recent developments in systems biology and their applications in cancer-related research. The ongoing advances in our understanding of genomics and proteomics, coupled with the development of new and more robust tools, have led to an emphasis on analyzing biological systems at multiple levels. Thus, there is a need to integrate different types of data into a comprehensive "systems" view.Written by active researchers in the emerging areas, this book gives senior undergraduate students, graduate students and new researchers an idea of where the frontiers of systems biology are and an opportunity to learn high-throughput techniques in use. One of the particular emphases of the book is to elucidate the molecular mechanisms in cancer. The discovery of biomarkers and anti-cancer drugs using systems biology approach is also extensively discussed.
| List of Contributors | p. ix |
| Gene/Protein Networks and Pathways | p. 1 |
| Introduction to Systems Biology | p. 3 |
| Gene Network Construction for Molecular Regulation | p. 17 |
| Micro RNA Regulation in Cellular Networks | p. 35 |
| Disease Modules in Protein-Protein Interaction Networks | p. 47 |
| Biomolecular Pathway Modeling | p. 55 |
| High-Throughput Omics Data and Analysis | p. 85 |
| ChIP-Seq Analytics: Methods and Systems to Improve ChIP-Seq Peak Identification | p. 87 |
| Discovery of Transcription Factor Binding Sites and Its Applications in Cancer Study | p. 113 |
| Cancer Epigenomics | p. 129 |
| Cancer Phosphoproteomics: Tools and Emerging Applications for Mining the Phosphoproteome in Cancer Biology | p. 161 |
| Predicting MicroRNAs | p. 189 |
| MicroRNA Research in Cancer Biology: Databases and Tools | p. 209 |
| Applications for Biomarkers and Drug Discovery | p. 225 |
| The Application of the Next-Generation Sequencing Technologies in Cancer Research | p. 227 |
| Membrane Proteomics for the Opportunity of Cancer Biomarker and Drug Target Discovery | p. 259 |
| Structure-Based Systems Biology and Drug Design in Cancer Research | p. 287 |
| Discovering Drug Targets for Cancer Therapy | p. 299 |
| Index | p. 323 |
| Table of Contents provided by Ingram. All Rights Reserved. |
ISBN: 9789814324458
ISBN-10: 9814324450
Audience:
Tertiary; University or College
Format:
Hardcover
Language:
English
Number Of Pages: 350
Published: 30th April 2012
Dimensions (cm): 23.1 x 15.5
x 2.0
Weight (kg): 0.64
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