By: Jan Barciszewski (Editor), Brian F.C. Clark (Editor)

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RNA Biochemistry and Biotechnology describes various aspects of nucleic acid and protein structure, mainly RNA structure and proteins, interacting with specific RNA species. Papers deal with DNA protein interactions, telomerase, aminoacyl-tRNA synthetases, elongation factor Tu, DNA repair, RNA structure, NMR technology, RNA aptamer interaction of biological macromolecules with metal ions. Two papers deal with theoretical aspects of RNA structure production and computer modelling. Many papers describe the possibility of commercial application of RNA biotechnology. One article discusses the impact of direct democracy on basic science supporting biotechnology. Readership: Advanced graduate students, Ph.D. students and young scientists as well as specialists in the field.

Preface
List of Contributors
Why RNA?	p. 1
Algorithms and thermodynamics for RNA secondary structure prediction: a practical guide	p. 11
Recurrent RNA motifs: Analysis at the basepair level	p. 45
Towards the 3D structure of 5S rRNA	p. 63
Structure and dynamics of adenosine loops in RNA bulge duplexes. RNA hydration at the bulge site	p. 73
The structure and function of the ribozyme RNAse P RNA is dictated by magnesium(II) ions	p. 89
Metal ion-induced cleavages in probing of RNA structure	p. 111
Protein-DNA recognition	p. 123
Specific interaction between damaged bases in DNA and repair enzymes	p. 127
Telomeric DNA recognition	p. 139
Recognition of one tRNA by two classes of aminoacyl-tRNA synthetase	p. 143
Functional structures of class-I aminoacyl-tRNA synthetases	p. 149
Aminoacylation of tRNA induces a conformational switch on the 3'-terminal ribose	p. 159
Point mutants of elongation factor Tu from E. coli impaired in binding aminoaycl-tRNA	p. 169
RNA structure and RNA-protein recognition during regulation of eukaryotic gene expression	p. 195
RNA-aptamers for studying RNA protein interactions	p. 217
Probing of ribonucleoprotein complexes with site-specifically derivatized RNAs	p. 229
The IRE model for families of RNA structures: Selective recognition by binding proteins (IRPs), NMR spectroscopy and probing with metal coordination complexes	p. 241
Functional analysis of RNA signals in the HIV-1 genome by forced evolution	p. 249
Interaction of native RNAs with Tat peptides	p. 277
Biogenesis, structure and function of small nucleolar RNAs	p. 291
RNA structure modules with trinucleotide repeat motifs	p. 303
Phosphorothioate oligonucleotides as aptamers of retroviral reverse transcriptases	p. 315
Oxathiaphospholane method of the stereocontrolled synthesis of phosphorothioate analogues of oligonucleotides	p. 325
Towards improved applications of cell-free protein biosynthesis - the influence of mRNA structure and suppressor tRNAs on the efficiency of the system	p. 335
RNA on the web	p. 347
How risky is direct democracy for basic science?	p. 353
Subject Index	p. 363
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792358619
ISBN-10: 0792358619
Series: NATO Science Partnership Subseries 3: High Technology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 386
Published: August 1999
Dimensions (cm): 24.0 x 16.0
Weight (kg): 0.82