By: R.L. Khandelwal (Editor), Jerry H. Wang (Editor)

Hardcover

Click on the Google Preview image above to read some pages of this book!

This book, published in association with the journal MOLECULAR AND CELLULAR BIOCHEMISTRY , is dedicated to Ed Krebs and Eddy Fischer in celebration of their 1992 Nobel Prize in Physiology and Medicine. Reversible protein phosphorylation is a research field pioneered and developed by Krebs and Fischer. This book contains short reviews and original research papers contributed by Krebs and Fischer's coworkers, both former and current. The contents reflect the two-way interaction between protein phosphorylation and other biomedical research fields. The chapters are grouped into four sections. The first two deal with structure/function aspects of protein kinases and protein mechanisms. Unlike many other research fields, which undergo periods of intense activity and productivity followed by relative calm, the protein phosphorylation field enjoyed continued growth both in scope and intensity, and the pace of this growth has increased markedly in recent years. This volume will provide a glimpse of the dynamism and diversity of the research activity representative of the current state of the field.

Dedication to Drs. E. G. Krebs and E. H. Fischer	p. 1
Preface	p. 5
Expression, purification, characterization, and deletion mutations of phosphorylase kinase [gamma] subunit: identification of an inhibitory domain in the [gamma] subunit	p. 7
Interaction sites on phosphorylase kinase for calmodulin	p. 19
Preparation and functional characterization of a catalytically active fragment of phosphorylase kinase	p. 31
Development and characterization of fluorescently-labeled myosin light chain kinase calmodulin-binding domain peptides	p. 45
Autophosphorylation: a salient feature of protein kinases	p. 51
Expression of cGMP-dependent protein kinase in Escherichia coli	p. 71
Chicken smooth muscle myosin light chain kinase is acetylated on its NH[subscript 2]-terminal methionine	p. 81
Calcium/calmodulin-dependent protein kinase II: role in learning and memory	p. 93
In vitro substrate specificity of protein tyrosine kinases	p. 103
Mutagenesis of the catalytic subunit of rabbit muscle protein phosphatase-1	p. 113
Serine phosphorylation of protein tyrosine phosphatase (PTP1B) in HeLa cells in response to analogues of cAMP or diacylglycerol plus okadaic acid	p. 121
Purification and characterization of the human protein tyrosine phosphatase, PTP [mu], from a baculovirus expression system	p. 131
Protein tyrosine phosphatase activity in Leishmania donovani	p. 143
The phosphorylation of stathmin by MAP kinase	p. 151
Networking with mitogen-activated protein kinases	p. 157
Interleukin-8 activates microtubule-associated protein 2 kinase (ERK1) in human neutrophils	p. 171
Signal transduction through the cAMP-dependent protein kinase	p. 179
Casein kinase II in signal transduction and cell cycle regulation	p. 187
The MAP kinase cascade. Discovery of a new signal transduction pathway	p. 201
Does the insulin-mimetic action of vanadate involve insulin receptor kinase?	p. 211
Phosphorylation of vertebrate nonmuscle and smooth muscle myosin heavy chains and light chains	p. 219
Phosphorylation of myosin light chain kinase: a cellular mechanism for Ca[superscript 2+] desensitization	p. 229
The role of protein phosphorylation in the regulation of cyclic nucleotide phosphodiesterases	p. 239
Reversible phosphorylation of eukaryotic initiation factor 2[alpha] in response to endoplasmic reticular signaling	p. 255
On the importance of protein phosphorylation in cell cycle control	p. 267
Evidence for an extra-cellular function for protein kinase A	p. 283
In situ regulation of cell-cell communication by the cAMP-dependent protein kinase and protein kinase C	p. 293
A-Kinase Anchoring Proteins: a key to selective activation of cAMP-responsive events?	p. 309
Index	p. 321
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792326373
ISBN-10: 0792326377
Series: Developments in Molecular and Cellular Biochemistry
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 330
Published: 1994
Dimensions (cm): 28.0 x 21.0  x 2.3
Weight (kg): 0.669