Physical Activity and Type 2 Diabetes
Therapeutic Effects and Mechanisms of Action
Table of Contents
Aetiology of Insulin Resistance and Type 2 Diabetes: Prevalence and Consequences of the "Diabesity" Epidemic The Increasing Burden of Type 2 Diabetes: Magnitude, Causes, and Implications of the Epidemic Trends in Prevalence and Incidence Risk Factors for Diabetes and Causes of the Epidemic Determinants of Recent Trends in the Epidemic Anticipated Consequences of Diabetes and the Outlook for Prevention Concluding Remarks Waging War on Type 2 Diabetes: Primary Prevention Through Exercise Biology Scope of the Problem Rationale for action Physical Inactivity's Contributing Role in the Pathogenesis of Diabetes New Ammunitions Future Battle Plans Concluding Remarks Defects in Metabolism and Insulin Resistance Fatty Acid Uptake and Insulin Resistance LCFAS and Their Uptake Across the Sarcolemma Fatty Acid Transporters Fatty Acid Transport and Transporters in Human Obesity and Type 2 Diabetes Concluding Remarks Lipid Metabolism and Insulin Signaling Lipid Metabolism in Skeletal Muscle The Insulin-Signaling Pathway Does Lipid Exposure Impair Insulin Action? Perturbations in Lipid Metabolism, Insulin Signal Transduction, and Insulin Action With Type 2 Diabetes and Obesity The Exercise Paradox Effect of Weight Loss on Muscle Lipid Accumulation and Insulin Signaling Concluding Remarks Metabolic Inflexibility and Insulin Resistance Substrate Utilization During Resting Conditions in Lean, Healthy Individuals Substrate Utilization in Insulin-Resistant Individuals Potential Cellular Mechanisms for Metabolic Flexibility in Fat Oxidation Effects of Weight Loss on Metabolic Flexibility in Obesity and T2DM Effects of Exercise Training on Metabolic Flexibility in Obesity and T2DM Concluding Remarks Nutrient Sensor Links Obesity With Diabetes Risk Nutrient Sensing and Control of Food Intake Overnutrition, Disruption of Homeostatic Control, and Insulin Resistance Cellular Nutrient Sensing Concluding Remarks Inflammation-Induced Insulin Resistance in Obesity: When Immunity Affects Metabolic Control Obesity Is a Chronic Low-Grade Inflammatory State Evolution of Inflammation in Obesity Lipid Mediators Protein Kinase Mediators Transcriptional Mediators Concluding Remarks Prevention of Type 2 Diabetes Through Exercise Training Transcription Factors Regulating Exercise Adaptation Activation of MAP Kinase Signaling Factor of Activated T Cells (NFAT) Regulation of GLUT4 Expression Mitochondria Biogenesis and Increased Lipid Oxidation Exercise-Mediated Regulation of PPARs Peroxisome Proliferators Activated Receptor Gamma Coactivator (PGC)-1 Concluding Remarks Exercise and Calorie Restriction Use Different Mechanisms to Improve Insulin Sensitivity Exercise and Calorie Restriction Effects on Skeletal Muscle Energy Status Exercise/Contraction-Stimulated Signaling Pathway for Glucose Transport Exercise Training Effects on Insulin Sensitivity and Insulin Signaling Effects of Calorie Restriction Distinct From Weight Loss Effects of Calorie Restriction on Insulin Signaling in Skeletal Muscle Combined Effects of Exercise and Calorie Restriction Concluding Remarks Mitochondrial Oxidative Capacity and Insulin Resistance An Overview of Mitochondrial Structure and Function Evidence for a Role for Mitochondria in Insulin Resistance and Diabetes Evidence That Mitochondria Are Not Responsible for Insulin Resistance Concluding Remarks Effects of Acute Exercise and Exercise Training on Insulin Action in Skeletal Muscle Exercise and Contraction Signaling in Muscle Insulin Signaling: A Web Effect of a Single Bout of Exercise on Insulin Sensitivity Effects of Exercise Training on Insulin Action Concluding Remarks Resistance Exercise Training and the Management of Diabetes Resistance Training and Insulin Sensitivity Mechanisms Behind Resistance Training-Induced Improvements in Insulin Sensitivity Training-Induced Gene Expression Conclusion and Perspectives Concluding Remarks Prevention of Type 2 Diabetes: Identification of Novel Molecular Targets and Pathways AMPK: The Master Switch for Type 2 Diabetes? Discoveries Suggesting AMPK Could Be Important for Prevention and Treatment of Type 2 Diabetes Could Type 2 Diabetes Be a Consequence of Deficiency in AMPK Signaling? How Can AMPK Activation Help Prevent Type 2 Diabetes? Can Chemical AMPK Activation Prevent Diabetes? Feasibility of Using AMPK Activators Future Directions Concluding Remarks Protein Kinase C and Insulin Resistance The PKC Family of Serine or Threonine Kinases Roles for PKC in Normal Glucose Homeostasis PKC and Defective Glucose Disposal Concluding Remarks Evidence for the Prescription of Exercise as a Therapy for the Treatment of Patients With Type 2 Diabetes Options for the Treatment of Insulin Resistance and Type 2 Diabetes Molecular Evidence for the Prescription of Exercise Training Exercise and Drug Combination Therapy Exercise-Like Effects of Current Antihyperglycemic Drugs Prescription of Exercise Training: Practical Considerations Concluding Remarks Table of Contents provided by Publisher. All Rights Reserved.
Number Of Pages: 232
Published: 19th April 2008
Publisher: Human Kinetics Publishers USA
Country of Publication: US
Dimensions (cm): 28.7 x 22.3 x 2.2
Weight (kg): 0.88
This product is categorised byNon-Fiction » Family & Health » Popular Medicine & Health
Non-Fiction » Medicine » Clinical & Internal Medicine » Endocrinology » Diabetes
Non-Fiction » Medicine » Medicine in General » Medical Equipment & Techniques » Medical Research
Non-Fiction » Medicine » Pre-Clinical Medicine & Basic Sciences » Physiology » Metabolism
Non-Fiction » Sports & Recreation » Sports Training & Coaching
This title provides students, scientists and health care clinicians with state-of-the-art information on the role of physical activity in alleviating insulin resistance. This book discusses the emergence of an exercise-deficient phenotype and details the effects of exercise training on selected aspects of substrate metabolism. The role of exercise interventions and endurance and resistance training programmes, for the prevention and treatment of insulin resistance are also covered. It includes recent developments in molecular and cellular biology that have led to the identification of novel targets and pathways for the treatment of insulin resistance and Type 2 diabetes.
About the Author
John Hawley is currently Director of the Exercise Metabolism Research Group and Professor of Exercise Metabolism in the School of Medical Sciences at RMIT University, Melbourne, Australia. He has published over 140 peer-reviewed scientific papers, written over 80 articles for technical journals and has authored numerous book chapters for sports medicine and exercise biochemistry texts. Juleen Zierath is professor of physiology and head of section of integrative physiology at the department of surgical science, Karolinska Institutet, Stockholm, Sweden. Zierath is also an adjunct professor of biochemistry at Boston University School of Medicine.