By: J. Hacker (Editor), James B. Kaper (Editor)

Hardcover

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It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important role in pathogenesis due to the intestinal E. coli as well due to Shigellae. Another interesting aspect which is reflected in different articles is that genomes evolve by acquisition of new pieces of DNA following gene transfer, but also by genome reduction. Different mechanisms include the deletion of sequences or the elimination of functions by the accumulation of point mutations or rearrangements.

From the reviews: "In addition to classic mutational events, a highly successful strategy of generating genetic diversity in bacteria is the acquisition of genomic islands. ... This compendium ... features an international assembly of authors including W. Arber (Basel) giving a lucid introduction into the evolution of prokaryotic genomes. The two-volume work provides a comprehensive overview of the current state of knowledge on PAIs and other mobile virulence determinants in bacterial as well as fungal pathogens of humans and plants." (Susanne Rohrer, BioWorld, Issue 6, 2002)

Evolution of prokaryotic genomes
Extraintestinal Escherichia coli as a model system for the study of pathogenicity islands
Pathogenicity islands fo intestinal E. coli
Pathogenicity islands of Shigella
Pathogenicity islands and host adaptation of Samonella serovars
Plasmids and pathogenicity islands of Yersinia
Genomic structure of LPS-specific loci
Genomic structure of capsular determinants
Genome Plasticity of Pathogenic and Non-Pathogenic Enterobacteria
Phylogenetic Relationships and Virulence Evolution in the Genus Bordetella
Pathogenicity Islands and PAI-Like Structures in Pseudomonas Species
Subject Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9783540426813
ISBN-10: 3540426817
Series: Current Topics in Microbiology and Immunology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 251
Published: January 2002
Dimensions (cm): 23.4 x 15.6  x 1.5
Weight (kg): 0.532