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Written in a clear and engaging style, and profusely illustrated with superb computer graphics, Introduction to Protein Architecture is a textbook for second and third year undergraduate students and beginning post-graduate students, and will be of interest to all biological and medical scientists whose work touches on proteins.
The structures and functions of proteins unlock the secrets inherent in genomes, including the human genome. The emphasis of this book is on protein architecture, on proteins as three-dimensional patterns. A new field, bioinformatics, has grown up around gene and protein sequences and structures. It has captured the interest of many scientists for its intellectual challenges, its potential for useful applications, and promising scope for careers. This book introduces the use of the World Wide Web in bioinformatics.
Written by one of the leaders in this field, Introduction to Protein Architecture explains the general characteristics of proteins that underlie the very great variety of folding patterns observed in nature. For specialists in structural biology, it contains the core of what they need to know. For students and workers in related disciplines, undergraduates or beginning graduate students in biology, chemistry, medicine, bioinformatics, and related fields it contains what they will be able to apply to their own work. Topics treated include: Pattern and form in protein structure; The building blocks; The relationship between amino acid sequence and protein structure; Secondary, supersecondary and tertiary structure; Classifications and hierarchies of protein folding patterns; Protein evolution; How proteins change conformation (and why).
To suit the needs of courses, each chapter includes recommended reading, lists of useful web sites, traditional exercises, and a new type of exercise called a weblem, for WEB-based probLEM.
This is truly a monument to the architecture of proteins: a gorgeous tour of the structures that dwell within us. The "frozen music" of biology is clearly presented in beautiful detail. The text should be considered for any introductory graduate level course in biochemistry.
|The photosynthetic reaction centre: protein structure in a microcosm|
|The reaction centre from Rhodopseudomonas viridis|
|In vivo, in vitro, in silicio|
|Why study proteins?|
|Protein structure and conformation|
|The known protein structures|
|The Protein Data Bank|
|The World Wide Web|
|Pattern and form in protein structure|
|Helices and sheets|
|The hierarchical nature of protein architecture|
|An album of small structures|
|Classification of protein structures|
|The varieties of protein structure|
|Catalogues of protein structure|
|The known structures|
|a + B proteins|
|a / B proteins|
|Closed B-a-B barrel structures|
|Evolution of DNA and proteins|
|Evolution of protein structures|
|Structural relationships among related molecules|
|Evolution in selected protein families|
|Evolution of the globins|
|Evolution of serine proteinases of the chymotrypsin family|
|NAD-binding domains of dehydrogenases|
|Some proteins of the immune system|
|Proteins of the Major Histocompatibility Complex|
|Conformational changes in proteins|
|Structural changes arising from change in state of ligation|
|Hinge motions in proteins|
|The 'helix interface shear' mechanism of conformational change|
|The allosteric change in haemoglobin|
|Serpins: SERine Proteinase INhibitors|
|Higher-level structural changes|
|An album for browsing|
|Useful web sites|
|Table of Contents provided by Publisher. All Rights Reserved.|
Audience: Tertiary; University or College
Published: 1st January 2001
Publisher: Oxford University Press
Dimensions (cm): 24.6 x 18.9 x 2.3
Weight (kg): 0.699