1300 187 187
The current understanding of cholesterol transport has moved from a largely descriptive science into the molecular stage. Intracellular Cholesterol Trafficking reports on the current state of research and features sections on: The Regulation of ACAT and Intracellular Cholesterol Level Niemann-Pick Type C Disease Cholesterol Transport in Specialized Cells Sterol Carrier Protein-2 and Cholesterol Transport Proteins Caveolae and Caveolin Summary and Future Perspectives . Intracellular Cholesterol Trafficking is sure to appeal to cell biologists, biochemists, endocrinologists, hepatologists, and atherosclerosis researchers.
This book will be of undoubted value to those actively engaged in research on cholesterol transport. It would be a useful addition to most science libraries to allow consultation by those who wish greater knowledge on the topic but are not prepared to bear the cost of a personal copy.' James B.M. Rattray in Inform, 11 (2000)
| List of invited contributors | |
| Preface | |
| Regulation of ACAT and Intracellular Cholesterol Level | |
| The Sterol-Specific Regulation of ACAT-1 and SREBPs in Mammalian Cells and in Liver | p. 1 |
| Intracellular Cholesterol Movement and Homeostasis | p. 15 |
| Intracellular Sterol Esterification: Two Acyl CoA: Cholesterol Acyltransferases in Mammals | p. 29 |
| Sterol Esterification and Homeostasis in a Model Eukaryote | p. 43 |
| Niemann-Pick Type C Disease | |
| Cholesterol Distribution in Golgi, Lysosomes and Endoplasmic Reticulum | p. 53 |
| Analysis of Somatic Cell Mutants That Express Defective Intracellular Cholesterol Transport | p. 75 |
| What the Niemann-Pick Type C Gene Has Taught Us About Cholesterol Transport | p. 93 |
| Cholesterol Transport in Specialized Cells | |
| The Movement of Plasma Membrane Cholesterol Through the Cell | p. 109 |
| Cholesterol Trafficking in CACO-2 Cells | p. 123 |
| Efflux and Plasma Transport of Biosynthetic Sterols | p. 147 |
| Intramitochondrial Cholesterol Transfer in Steroidogenic Cells | p. 169 |
| Mechanisms and Consequences of Cholesterol Loading in Macrophages | p. 183 |
| Sterol Carrier Protein-2 and Cholesterol Transport Proteins | |
| Direct Evidence for Sterol Carrier Protein-2 (SCP-2) Participation in ACTH Stimulated Steroidogenesis in Isolated Adrenal Cells | p. 197 |
| Intracellular Sterol Binding Proteins: Cholesterol Transport and Membrane Domains | p. 213 |
| Functional Analysis of Sterol Carrier Protein-2 (SCP2) in the SCP2 Knockout Mouse | p. 235 |
| Caveolae and Caveolin | |
| Scavenger Receptors, Caveolae, Caveolin, and Cholesterol Trafficking | p. 253 |
| Selective Uptake of Lipoprotein-Free Cholesterol and Its Intracellular Transport - Role of Caveolin | p. 273 |
| Summary and Future Perspectives | p. 289 |
| Index | p. 297 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
ISBN: 9780792383659
ISBN-10: 0792383656
Audience:
Professional
Format:
Hardcover
Language:
English
Number Of Pages: 304
Published: November 1998
Weight (kg): 0.632
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