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Inflammatory Bowel Disease

Translation from Basic Research to Clinical Practice

By: B. Vucelic Zagreb (Editor), J. F. Colombel (Editor), C. Gasche (Editor), J. Scholmerich (Editor)

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The amount of information on the pathogenesis of inflammatory bowel disease is growing rapidly. This is reflected by a continuous increase in the number of papers presented at international GI meetings. To make things more difficult for practicing physicians, there is also a large number of new clinical trials being published which require periodical critical reviews and recommendations. Faced with these issues, the scientific commitee of the Falk Symposium No. 140 decided to take a different approach and to apply a novel format that is reflected in the title of the Symposium: "Translation from basic research to clinical practice".

This book contains the proceedings of that Symposium, held in Dubrovnik, Croatia, on May 7-8, 2004. The sections are designed so that they start with the information from basic sciences on different aspects of these complex diseases and further lead to their clinical implications. Special attention is paid to the mechanisms of actions of established drugs. The last two sections are clinically oriented and focus on the most difficult aspects of both Crohn's disease and ulcerative colitis. This format provides state-of-the-art chapters by leading experts in the field and at the same time up-to-date information on the clinical application of the new knowledge.

List of principal contributorsp. 000
Prefacep. 000
Genetics
Molecular classification of inflammatory bowel diseasep. 3
NOD proteins and defence against microbial infectionp. 17
Pharmacogenetics of inflammatory bowel disease therapyp. 24
Genotypes and phenotypes in clinical practicep. 34
Microbiology
Chronic inflammatory disorders, the gut and the `Old Friends' hypothesisp. 43
Innate immune receptors and inflammatory bowel diseasep. 59
Manipulation of enteric flora in clinical practicep. 66
Immunoregulation: Novel Therapeutic Agents
Lymphocyte integrins and the pathogenesis of experimental colitisp. 75
Role of cytokines and their receptors in inflammatory bowel diseasesp. 83
State-of-the-art: targeting immunoregulation - biologicalsp. 90
Manipulation of the Environment
Environmental epidemiologyp. 101
Understanding the opposite effects of smoking in inflammatory bowel diseasep. 112
Microparticles: a link between modern life and inflammatory bowel disease?p. 123
Are we able to treat inflammatory bowel disease with diet?p. 138
New Diagnostic Tools
Novel endoscopic diagnostic developments - bioendoscopyp. 149
Cross-sectional imaging in inflammatory bowel diseasep. 154
State-of-the-art: the transparent abdomenp. 158
Mechanism of Action of Established Drugs
Apoptosis as a targetp. 167
Mechanisms of action of conventional drugs in inflammatory bowel diseasep. 173
Optimizing the use of current drugs for inflammatory bowel diseasep. 180
The Difficult Cases of Crohn'S Disease
Diffuse jejunoileitis in an adolescentp. 189
Diffuse jejunoileitis in the adolescent patientp. 196
Current methods of bowel-sparing surgery in Crohn's diseasep. 202
Mechanisms of steroid-refractory diseasep. 220
Management of perianal Crohn's diseasep. 234
The Difficult Cases of Ulcerative Colitis
A case of refractory proctitisp. 243
Inflammatory bowel diseases and innate immunityp. 249
Biology of cancer in ulcerative colitis and consequences for chemopreventionp. 259
Therapeutic strategy in ulcerative colitis - 2004p. 270
Indexp. 275
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9781402028472
ISBN-10: 1402028474
Series: Falk Symposium
Audience: Professional
Format: Hardcover
Language: English
Published: 1st May 2005
Dimensions (cm): 23.4 x 15.6  x 1.9
Weight (kg): 0.609