By: S.Tsuyoshi Ohnishi (Editor), Tomoko Ohnishi (Editor)

Hardcover

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Central nervous system trauma, which
encompasses stroke, subarachnoid hemorrhage, head injury, and spinal cord injury, is a leading cause of death in developed countries. In the search for underlying mechanisms, membrane involvement has been the common link. This fourth volume in the Membrane-Linked Diseases series is therefore dedicated to research on CNS trauma.
Focusing on the mechanism of membrane damage, Central Nervous System Trauma: Research Techniques presents a variety of experimental techniques to study the mechanism of CNS trauma. Animal and tissue culture models provide the bulk of the research findings in this area. Possible pharmacological interventions are analyzed. This volume offers numerous illustrative examples, including full color figures. This book serves as a valuable resource for students and researchers, assisting in the comprehension of current trends in CNS trauma and helping to stimulate the discovery of new research areas.

CNS Trauma Research Using Small Animals	p. 3
Effects of Hypoxia and Hyperoxia on CNS	p. 7
Role of Calcium in CNS Trauma	p. 59
Role of Magnesium in CNS Trauma	p. 75
Ion Movements and Edema Formation in CNS Injury	p. 85
A Global Ischemia Model: The Use of Na, K-ATPase Analysis	p. 97
Forebrain Ischemia in the Rat: The Four-Vessel Occlusion Model	p. 107
A Focal Cerebral Ischemia Model Designed for Basic Research and Experimental Interventions	p. 119
Reversible Focal Cerebral Ischemia in Rats: Middle Cerebral Artery Occlusion by Intraluminal Suture	p. 131
A Model of Transient Focal Cerebral Ischemia in the Mouse	p. 139
Murine Models of Cerebral Ischemia	p. 147
Concepts and Techniques of Experimental Stroke Induced by Cerebrovascular Photothrombosis	p. 169
Subarachnoid Hemorrhage Model	p. 195
The Mouse Head Injury Model: Utility in the Discovery of Acute Cerebroprotective Agents	p. 213
Simple Controlled Cortical Impact Models of Mouse Head Injury	p. 225
A Closed Head Injury Model	p. 235
Weight Drop Model of Traumatic Brain Injury: Assessment of the Acute Inflammatory Response to Cerebral Trauma	p. 247
Rodent Models of Traumatic Brain Injury and Motor Function Assessment: Controlled Cortical Impact and Fluid Percussion Models of Traumatic Brain Injury	p. 255
A Model of Spinal Cord Ischemia	p. 267
Spinal Cord Injury Modeling and Functional Assessment	p. 281
A Weight Free-Drop Technique to Produce Spinal Cord Injury and a Simple Motor Function Test	p. 297
The Assessment of Cognitive Function Following Traumatic Brain Injury	p. 307
In Vitro Models of Ischemic Injury	p. 321
Brain Slices in the Study of CNS Trauma	p. 329
Organotypic Spinal Cord Cultures and A Model of Chronic Glutamate-Mediated Motor Neuron Degeneration	p. 341
Tissue Culture Studies of Neuronal Responses to Physical Lesions of the Plasma Membrane: Environmental Influences and Experimental Interventions	p. 353
Application of Microdialysis for CNS Injury Study	p. 377
Measurement of Glutamate and Other Neurotransmitters in Ischemic Brain by Microdialysis: Effect of Hypothermia and Hyperthermia	p. 395
A Microdialysis Model for Identifying Agents of Secondary Damage in Spinal Cord Injury	p. 405
Postischemic Gene Regulation	p. 417
SOD-1 Transgenic Mice: An Application to the Study of Ischemic Brain Injury	p. 425
Improvements in the Salicylate Trapping Method for Measurement of Hydroxyl Radical Levels in the Brain	p. 437
Trapping of Oxygen Free Radicals During Brain Ischemia and Reperfusion	p. 445
Trapping of Nitric Oxide Radicals in Brain Ischemia	p. 455
Direct Measurement of Nitric Oxide in the Rat Brain Subjected to the Occlusion of the Middle Cerebral Artery	p. 471
Nitric Oxide and Superoxide-Mediated Tissue Injury: Detection of Peroxynitrite	p. 485
Histopathology After Traumatic Brain Injury	p. 497
Biochemical Immunohistology	p. 509
Chronic Alcoholism and Brain Ischemia	p. 519
Gun Shot Wounds to the Brain	p. 523
Index	p. 545
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780849380945
ISBN-10: 0849380944
Series: Membrane-linked Diseases S.
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 592
Published: 27th July 1995
Dimensions (cm): 25.4 x 17.8  x 2.8
Weight (kg): 1.474