By: Sidney M. Hecht (Editor)

Hardcover

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Bioorganic chemistry has expanded rapidly over the past two decades, enriching the disciplines of biology and chemistry and providing important insights into the workings of biological systems at a molecular level. Recently, this growing field has witnessed some very exciting results in applying design and synthesis techniques to many problems in molecular biology. Much of the current work in areas such as protein folding, signal transduction, molecular recognition, monoclonal antibodies, and drug design is being conducted by bioorganic chemists. Bridging the gap between chemistry and biology, Topics in Bioorganic and Biological Chemistry, A Series of Books in Support of Teaching and Research is a novel resource designed to serve the needs of the many graduate students, professionals, and researchers who work and study in these fields by concisely summarizing a range of topics which constitute the core of expertise in this emerging discipline.
This first volume, Bioorganic Chemistry: Nucleic Acids provides an overview of DNA and RNA, including coverage of biosynthesis, structure, and their functions in information storage and transmission. Special emphasis is given to the manner in which the individual chemistries of DNA and RNA conduce to their specific functions. The chemistry of molecules that disrupt nucleic acid biosynthesis and functions, antisense technologies involving RNA and DNA, and naturally occurring ribozymes are also covered. Each chapter begins with an introduction that includes basic principles, a summary of key findings which support current research in the field, and an overview of current research activity. The remainder of each chapter deals in greater detail with a number of recent studies that illustrate the nature of ongoing activity in the field.
Edited by one of the world's top researchers and featuring contributions from accomplished researchers, Bioorganic Chemistry is a state of the art, accessible account of the subject area which offers readers insights into the most current directions of research and important applications. Bioorganic Chemistry comprises three volumes: Nucleic Acids; Peptides and Proteins; and Carbohydrates.

"It is an excellent starting point for any chemist seeking to familiarize him- or herself with current topics related to the chemistry, enzymology, molecular recognition, and structure of nucleic acids....This book succeeds in presenting a clear, yet suitabley advanced view of modern nucleic acid chemistry and thus will prove very useful to educators, students, and established researchers who are interested in this field." -- Journal of the American Chemical Society "...the editor and his contribuators have succeeded admirably in producing a modestly priced book that will be very useful, not only for its target audience of students but for anyone wishing to have a concise yet thorough overview of the field."--Manfred E. Wolff, Journal of Medicinal Chemistry

Preface List of Contributors 1: Eric C. Long: Fundamentals of Nucleic Acids 2: Serge L. Beaucage and Marvin H. Caruthers: The Chemical Synthesis of DNA/RNA 3: Mark Van Cleve: Enzymatic Methods for the Preparation and Manipulation of Nucleic Acids 4: M. Sriram and Andrew H.J. Wang: Structure of DNA and RNA 5: Thomas D. Tullius: Chemical Mapping of Nucleic Acid Conformation 6: Kenneth J. Addess and Juli Feigon: Introduction to H NMR Spectroscopy of DNA 7: David M. J. Lilley: The Formation of Alternative Structures in DNA 8: Maryanne J. O'Donnell and Larry W. McLaughlin: Reporter Groups for the Analysis of Nucleic Acid Structure 9: Sergei A. Kazakov: Nucleic Acid Binding and Catalysis by Metal Ions 10: John A. Mountzouris and Laurence H. Hurley: Small Molecule-DNA Interaction 11: Christopher J. Larson and Gregory L. Verdine: The Chemistry of Protein-DNA Interactions 12: Paul S. Miller: Antisense/Antigene Oligonucleotides 13: Francis J. Schmidt: Catalytic RNA 14: Reuel B. Van Atta and Sam J. Rose: The Polymerase Chain Reaction and In Vitro Random Selection References Index

ISBN: 9780195084672
ISBN-10: 0195084675
Series: Topics in Bioorganic and Biological Chemistry
Audience: Tertiary; University or College
Format: Hardcover
Language: English
Number Of Pages: 506
Published: 18th April 1996
Dimensions (cm): 23.4 x 15.6  x 2.9
Weight (kg): 0.91