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Advances in DNA Sequence - Specific Agents

v. 4

By: Graham B. Jones (Editor), Brant J. Chapman (Editor)

Hardcover

Published: 17th September 2002
RRP $141.95
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This series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro) for the study of these critical interactions. As our understanding of the genome and proteome expands, general developments in the field of DNA sequence specific interaction are likely to play an increasingly important role. Accordingly, manuscripts have been solicited from experts covering a diverse range of fields, reflecting the cross-disciplinary and dynamic nature of the series.


Volume 4 describes work on the modification of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective binders, bulged DNA microenvironments as molecular targets, DNA sequence specific binding by short peptides and the analysis of DNA-protein interactions using DNase I footprinting methodology.


Features include:
- Expert contributors from the Biomedical world
- Emerging areas of drug design and therapeutic applications
- Nucleic acid-protein interactions
- Color graphics of molecular modeling analyses
- New and emerging methodologies

Preferential damage to defined regions of genomic DNA by AT-specific anticancer drugs
DNA-alkylating events associated nitrogen mustard based anticancer drugs and the metabolic byproduct acrolein
Molecular basis for recognition and binding of specific DNA sequences by calicheamicin and duocarmycin
Enediyne antibiotic neocarzinostatin as a radical-bsed probe of bulged structures in nucleic acids
Sequence-specific DNA binding by short peptides
Equilibrium and kinetic quantitative DNAse I footprinting
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780444510969
ISBN-10: 0444510966
Series: Advances in DNA Sequence - Specific Agents
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 162
Published: 17th September 2002
Publisher: Elsevier Science & Technology
Dimensions (cm): 24.0 x 16.5  x 1.3
Weight (kg): 0.454